کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162654 | 1114336 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tablet Disintegration Studied by High-Resolution Real-Time Magnetic Resonance Imaging
ترجمه فارسی عنوان
تجمع قرص با تصویربرداری رزونانس مغناطیسی با رزولوشن بالا با رزولوشن بالا
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The present work employs recent advances in high-resolution real-time magnetic resonance imaging (MRI) to investigate the disintegration process of tablets containing disintegrants. A temporal resolution of 75 ms and a spatial resolution of 80 à 80 μm with a section thickness of only 600 μm were achieved. The histograms of MRI videos were quantitatively analyzed with MATLAB. The mechanisms of action of six commercially available disintegrants, the influence of relative tablet density, and the impact of disintegrant concentration were examined. Crospovidone seems to be the only disintegrant acting by a shape memory effect, whereas the others mainly swell. A higher relative density of tablets containing croscarmellose sodium leads to a more even distribution of water within the tablet matrix but hardly impacts the disintegration kinetics. Increasing the polacrilin potassium disintegrant concentration leads to a quicker and more thorough disintegration process. Real-time MRI emerges as valuable tool to visualize and investigate the process of tablet disintegration. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:249-255, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 1, January 2014, Pages 249-255
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 1, January 2014, Pages 249-255
نویسندگان
Julian Quodbach, Amir Moussavi, Roland Tammer, Jens Frahm, Peter Kleinebudde,