کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10162693 1114349 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elucidation of Release Characteristics of Highly Soluble Drug Trimetazidine Hydrochloride from Chitosan-Carrageenan Matrix Tablets
ترجمه فارسی عنوان
توضیح ویژگی های انتشار تری متیازیدین هیدروکلراید از داروهای بسیار تسکین دهنده از قرص های ماتریکس کیتوزان-کاراژین
کلمات کلیدی
کیتوزان، کاراژین، تریماتازیدین هیدروکلراید، ویژگی های انتشار، قرص پیچیدگی تحویل داروی خوراکی، آزادی کنترل تداخل مواد مخدر، پلیمرهای زیست تخریب پذیر،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
The aim of this study was to better understand the underlying drug release characteristics from matrix tablets based on the combination of chitosan (CS) and different types of carrageenans [kappa (κ)-CG, iota (ι)-CG, and lambda (λ)-CG]. Highly soluble trimetazidine hydrochloride (TH) was used as a model drug. First, characteristics of drug release from different formulations were investigated, and then in situ complexation capacity of CG with TH and CS was studied by differential scanning calorimetry and Fourier transform infrared spectroscopy. Erosion and swelling of matrix were also characterized to better understand the drug-release mechanisms. Effects of pH and ionic strength on drug release were also studied. It was found that not only ι-CG and λ-CG could reduce the burst release of TH by the effect of TH-CG interaction, CS-ι-CG- and CS-λ-CG-based polyelectrolyte film could further modify the controlled-release behavior, but not CS-k-CG. High pH and high ionic strength resulted in faster drug release from CS-κ-CG- and CS-ι-CG-based matrix, but drug release from CS-λ-CG-based matrix was less sensitive to pH and ionic strength. In conclusion, CS-λ-CG-based matrix tablets are quite promising as controlled-release drug carrier based on multiple mechanisms. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2644-2654, 2013
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 8, August 2013, Pages 2644-2654
نویسندگان
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