کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10231520 1204 2015 39 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
چکیده انگلیسی
In this review we analyse structure/sequence-function relationships for the superfamily of PLP-dependent enzymes with special emphasis on class III transaminases. Amine transaminases are highly important for applications in biocatalysis in the synthesis of chiral amines. In addition, other enzyme activities such as racemases or decarboxylases are also discussed. The substrate scope and the ability to accept chemically different types of substrates are shown to be reflected in conserved patterns of amino acids around the active site. These findings are condensed in a sequence-function matrix, which facilitates annotation and identification of biocatalytically relevant enzymes and protein engineering thereof.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 33, Issue 5, September–October 2015, Pages 566-604
نویسندگان
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