کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10231950 | 1423 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pattern-constrained multiple polypeptide sequence alignment
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pattern-constrained multiple polypeptide sequence alignment Pattern-constrained multiple polypeptide sequence alignment](/preview/png/10231950.png)
چکیده انگلیسی
Multiple sequence alignment (MSA) is one of the fundamental research topics in computational biology. The alignments help us to find functional assignment, evolutionary history and conserved region. Previous methods use a substitution matrix and do not incorporate knowledge of the sequences being aligned. Therefore, they do not assure the alignment of similar structures and common patterns in the sequences. We have been investigating into the solution to the problem in multiple and making use of knowledge of the sequences being aligned, including patterns in the Prosite databank, Blocks+, eBlocks databases, as well as motif and structural information. A pattern-constrained algorithm has been developed. Experiments with protein sequences have shown more accurate alignments with incorporation of the domain knowledge available in the sequences.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Biology and Chemistry - Volume 29, Issue 4, August 2005, Pages 303-307
Journal: Computational Biology and Chemistry - Volume 29, Issue 4, August 2005, Pages 303-307
نویسندگان
Zhihua Du, Feng Lin,