کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10231955 1425 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Folding degrees of azurins and pseudoazurins
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Folding degrees of azurins and pseudoazurins
چکیده انگلیسی
A quantitative measure of the degree of folding of azurins and pseudoazurins has been made. We have found that the reduction potential of azurins and pseudoazurins is a function of the contribution to the degree of folding of His117, a key amino acid in electron transfer which is directly bonded to copper in these proteins. The folding degree of His117 explains 95% of the variance in the experimental values of the reduction potential of azurins and pseudoazurins. The change in the folding degree of this amino acid influences several geometric parameters of the main backbones of these proteins. Among them, the angle formed between N(His117)⋯Cu⋯S(Cys112), which plays an important role in electron transport, but not the N(His117)⋯Cu distance, shows some non-linear correlation with the reduction potential of azurins and pseudoazurins. However, it is only able to explain less than 75% in the variance of the reduction potential of these proteins instead of the 95% explained by the folding degree of His117.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Biology and Chemistry - Volume 29, Issue 5, October 2005, Pages 345-353
نویسندگان
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