Enzymatic modification of 2,6-dimethoxyphenol for the synthesis of dimers with high antioxidant capacity

► Laccase-catalysed oxidation of 2,6-dimethoxyphenol produces a symmetrical CC dimer. ► Production of the dimer is enhanced through 'medium engineering' in organic solvents. ► The dimer shows superior (≈2×) antioxidant capacity than the substrate.