کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10255036 | 161485 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunoglobulin G is the only anti-beta-2-glycoprotein I isotype that associates with unprovoked thrombotic events among hospital patients
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی قانونی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study aimed to determine the strength of association between anti-beta-2-glycoprotein I (anti-β2GPI) isotypes and thrombotic events by phenotyping hospital patients tested for diagnostic purposes with at least one positive anti-β2GPI isotype. A laboratory database search identified patients who had undergone anti-β2GPI testing during a 3 year period. Medical records of patients with a positive anti-β2GPI result were reviewed and clinical events ascertained. Thromboses were subdivided into provoked and unprovoked, depending on the stated aetiology. A total of 128 patients had at least one positive anti-β2GPI isotype. There was a higher proportion of unprovoked thromboses among patients who were IgG anti-β2GPI positive compared to those who lacked IgG anti-β2GPI (20/30 versus 20/98). Median IgG anti-β2GPI levels were higher among patients with unprovoked events compared to those without (22.5 SGU versus 2 SGU). Retrospective assessment of anti-β2GPI testing strategies showed that testing IgM and/or IgA anti-β2GPI after IgG anti-β2GPI captured a greater number of non-thrombotic events and provoked thromboses than unprovoked thromboses. IgG anti-β2GPI associates most strongly with clinical events characteristic of antiphospholipid syndrome (APS). These results suggest that IgG anti-β2GPI is superior to IgM and IgA anti-β2GPI in the assessment of hospital patients with potential APS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 46, Issue 3, April 2014, Pages 234-239
Journal: Pathology - Volume 46, Issue 3, April 2014, Pages 234-239
نویسندگان
Anna Brusch, Christine Bundell, Peter Hollingsworth,