Preparation and physicochemical characterization of trans-resveratrol nanoparticles by temperature-controlled antisolvent precipitation

► Preparation of trans-resveratrol nanoparticles by temperature-controlled antisolvent precipitation. ► Lower precipitation temperature can produce a smaller particle size. ► The decrease in particle size down to nano-sized range and degree of crystallinity of trans-resveratrol. ► Significant enhancement of saturation solubility and dissolution rate of trans-resveratrol.