کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10298135 | 539139 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Premenstrual dysphoric disorder and prefrontal reactivity during anticipation of emotional stimuli
ترجمه فارسی عنوان
اختلال افسردگی قبل از قاعدگی و واکنش پیش فونتال در پیش بینی محرک های هیجانی
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کلمات کلیدی
ACCDSMDICOMBOLDDLPFCIAPSdigital imaging and communications in medicine - تصویربرداری دیجیتال و ارتباطات در پزشکیfMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیblood oxygenation level dependent - سطح اکسیژن خون وابسته استanterior cingulate cortex - قشر سینگولیت قدامی، کورتکس سینگولیت قدامیdorsolateral prefrontal cortex - قشر پیشانی غدد درون رحمیBrodmann area - منطقه بردممنhealthy control - کنترل سالم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Premenstrual disorder (PMDD) affects around 5% of women in childbearing ages. An increased sensitivity in emotion processing areas of the brain to variations in ovarian steroid levels has been suggested as part of the pathophysiology in PMDD, but prior neuroimaging studies of emotion processing are yet inconclusive. Previous behavioral studies of women with PMDD have, however, reported enhanced luteal phase startle responsivity during emotional anticipation. Here we used functional magnetic resonance imaging (fMRI) to investigate central neural circuitry activity during anticipation of, and exposure to, emotional stimuli across the menstrual cycle in women with and without PMDD. As compared to healthy controls, women with PMDD displayed significantly enhanced reactivity in the prefrontal cortex during anticipation of, but not exposure to, negative emotional stimuli during the luteal phase. In PMDD patients, BOLD reactivity during anticipation or viewing of negative emotional stimuli was not dependent on absolute levels of estradiol or progesterone. However, progesterone levels were positively correlated with emotion-induced reactivity in the dorsolateral prefrontal cortex to positive emotional stimuli. These findings suggest that cortical emotional circuitry reactivity during anticipation is altered in PMDD during the luteal phase, which might be part of the pathophysiology behind the emotional symptoms or lack of emotional control reported by women with PMDD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 23, Issue 11, November 2013, Pages 1474-1483
Journal: European Neuropsychopharmacology - Volume 23, Issue 11, November 2013, Pages 1474-1483
نویسندگان
Malin Gingnell, Elin Bannbers, Johan Wikström, Mats Fredrikson, Inger Sundström-Poromaa,