کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10299210 | 539696 | 2014 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression
ترجمه فارسی عنوان
بررسی ویژگی های ضد افسردگی مهارکننده های سنتاز نیتریک اکسید در مدل موش صحرایی بذر افسردگی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
نیاسین اکسید سنتاز، ضد افسردگی، افسردگی، موش صحرایی میدان باز تصویربرداری رزونانس مغناطیسی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Nitric oxide synthase (NOS) inhibitors possess antidepressant-like properties in preclinical tests and in the current investigation the brain penetrant NOS inhibitor NÏ-nitro-l-arginine (l-NA) and the preferential inhibitor of neuronal NOS (nNOS) 1-(2-trifluoromethylphenyl) imidazole (TRIM) were assessed in the olfactory bulbectomised (OB) rat, a well-established animal model of depression. Magnetic resonance imaging (MRI) was employed to assess regional brain volumes, blood perfusion and T1 and T2 relaxometry times both with and without drug treatment. l-NA (10Â mg/kg, once daily p.o. for 10 days) attenuated OB-related hyperactivity in the “open field” test in a comparable fashion to the tricyclic antidepressant imipramine (20Â mg/kg, once daily p.o. for 14 days) indicative of an antidepressant-like response in the model. Treatment with TRIM (50Â mg/kg, once daily s.c.) attenuated OB-related hyperactivity following 7 days of treatment when compared to vehicle treated controls. OB is associated with enlarged ventricular volume, increased periventicular perfusion and a decrease in T2 relaxation times in cortical and hippocampal regions, with enhanced perfusion and reduced T2 times attenuated by l-NA treatment. l-NA treatment was also associated with an increase in T1 relaxation times in limbic and cortical regions and found to reduce resting state hippocampal blood perfusion in OB animals. Behavioural observations are consistent with an antidepressant action of NOS inhibitors where associated changes in perfusion and T2 relaxation times may be related to the antidepressant action of l-NA in the model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 24, Issue 8, August 2014, Pages 1349-1361
Journal: European Neuropsychopharmacology - Volume 24, Issue 8, August 2014, Pages 1349-1361
نویسندگان
Valentina Gigliucci, Shane Gormley, Sinead Gibney, Jennifer Rouine, Christian Kerskens, Thomas J. Connor, Andrew Harkin,