کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10299453 539720 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity
چکیده انگلیسی
Working memory (WM) is fractionated into systems for visuospatial and phonological information. Recently, it has been shown that the dopamine d2 receptor gene DRD2 and CHRNA4, the gene coding for the nicotinic acetylcholine receptor's alpha4 subunit, interact epistatically on visuospatial WM capacity. In the present study, we show a similar interaction on phonological WM capacity in N = 137 healthy subjects genotyped for two single nucleotide polymorphisms (DRD2 rs6277 and CHRNA4 rs1044396). Given the functional independence of the two systems we hypothesize that the genetic interaction targets the central executive which is the common control process for both systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 21, Issue 2, February 2011, Pages 216-220
نویسندگان
, , , ,