Prepubertal gonadotropin-releasing hormone analog leads to exaggerated behavioral and emotional sex differences in sheep

► Gonadotropin-releasing hormone (GnRH) affects developing sex differences in puberty. ► GnRH analog increased sex differences in pre-pubertally treated young sheep. ► Treated males showed exaggerated reward driven behavior and high emotional control. ► Treated females displayed avoidant oriented behavior and poor emotional control. ► GnRH analogs need to be evaluated as possible cognitive modulators.