کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10301535 | 540904 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of acidic-astressin and ovine-CRF microinfusions into the ventral hippocampus on defensive behaviors in rats
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کلمات کلیدی
i.c.v.BLAEPMintracerebroventricularbasolateral amygdaleoCRFCRFaCSFPMd - PMDStress - استرس یا فشار روانیAnxiety - اضطرابFear - ترسlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Defense - دفاعConditioning - شرطیشدنPredator - شکارچیcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینElevated plus-maze - ماز بعلاوه شکل مرتفعartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیRats - موش صحراییDorsal premammillary nucleus - هسته پرمامیلری پشتیHippocampus - هیپوکامپ ventral hippocampus - هیپوکامپ شکمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study investigated a possible role for ventral hippocampal corticotropin-releasing factor (CRF) in modulating both unconditioned and conditioned defensive behaviors by examining the effects of pre-training ventral hippocampal ovine-CRF (oCRF) or acidic-astressin ([Glu11,16]Ast) microinfusions in male Long-Evans hooded rats exposed to various threat stimuli including the elevated plus-maze (EPM) (oCRF), cat odor (oCRF and [Glu11,16]Ast) and a live cat ([Glu11,16]Ast). Unconditioned defensive behaviors were assessed during threat exposure, while conditioned defensive behaviors were assessed in each predator context 24Â h after the initial threat encounter. Pre-training infusions of the CRF1 and CRF2 receptor agonist oCRF significantly increased defensive behaviors during both the unconditioned and conditioned components of the cat odor test, as well as exposure to the EPM. In contrast to the behavioral effects of oCRF microinfusions, the CRF1 and CRF2 receptor antagonist [Glu11,16]Ast significantly decreased defensive behaviors during exposure to cat odor, while producing no discernible effects following a second injection in the cat exposure test. During conditioned test trials, pre-training infusions of [Glu11,16]Ast also significantly reduced defensive behaviors during re-exposure to both predator contexts. These results suggest a specific role for ventral hippocampal CRF receptors in modulating anxiety-like behaviors in several ethologically relevant animal models of defense.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 56, Issue 1, June 2009, Pages 35-43
Journal: Hormones and Behavior - Volume 56, Issue 1, June 2009, Pages 35-43
نویسندگان
Nathan S. Pentkowski, Yoav Litvin, D. Caroline Blanchard, Amy Vasconcellos, Lanikea B. King, Robert J. Blanchard,