کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10303669 | 545613 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stress induced by the socially evaluated cold-pressor test cause equivalent deficiencies of sensory gating in male subjects with schizophrenia and healthy controls
ترجمه فارسی عنوان
استرس ناشی از آزمایش فشارخون تحت بررسی اجتماعی، باعث کمبود معایب جراحی حسی در افراد مرد مبتلا به اسکیزوفرنی و کنترل سالم
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کلمات کلیدی
جنون جوانی، مهار پیشگیری، روانپزشکی، کورتیزول، فشار، تست سرماخوردگی به صورت اجتماعی ارزیابی شده است
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
It is known that patients with schizophrenia show a deficiency in the prepulse inhibition reflex (PPI). These patients display abnormalities in autonomic nervous system and hypothalamic-pituitary-adrenal function and may have an altered sensitivity to stress. To date, no studies have been carried out to determine the effect of acute stress on the PPI. We investigated whether there was a differential response in reactivity to acute stress caused by the socially evaluated cold-pressor test (SECPT) in a sample of 58 chronic male patients with schizophrenia and 28 healthy control subjects. PPI, salivary cortisol and heart rate (HR) were measured. The patients were evaluated in two sessions (with and without the SECPT) 72Â h apart and basal measurements were carried out and 30Â min post-startle probe. We found an increase in salivary cortisol levels and the HR with SECPT condition in both groups and a significantly lower PPI% in patients with schizophrenia. The most relevant findings of this study are that the impairment of the PPI is increased by stress. Stress-induced increase in cortisol in both groups, mainly in healthy control group which allows us to hypothesize that at least such deterioration may be due to the hypercortisolemia caused by the SECPT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 228, Issue 3, 30 August 2015, Pages 283-288
Journal: Psychiatry Research - Volume 228, Issue 3, 30 August 2015, Pages 283-288
نویسندگان
Gabriel Rubio, Francisco López-Muñoz, Rosa Jurado-Barba, Isabel MartÃnez-Gras, Roberto RodrÃguez-Jiménez, Regina Espinosa, Miguel Ángel Pérez-Nieto, Stephan Moratti, Miguel Ángel Jiménez-Arriero, Juan Carlos Leza,