کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10305823 | 547032 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18Â kDa Translocator Protein (TSPO)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18Â kDa Translocator Protein (TSPO) Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18Â kDa Translocator Protein (TSPO)](/preview/png/10305823.png)
چکیده انگلیسی
TSPO mediated transport of cholesterol into the mitochondrion is a necessary step in steroid synthesis. The rs6971 polymorphism in the TSPO gene causes an amino acid substitution (Ala147Thr) within the transmembrane domain where the cholesterol-binding pocket is located, and has been shown to affect the steroidogenic pathway. We report a nominal association between this TSPO polymorphism and the diagnosis of Bipolar Disorder in both the genome-wide dataset of the Wellcome Trust Case-Control Consortium and the Psychiatric Genome-Wide Association Study Consortium Bipolar Disorder group (OR = 1.11, p = 0.007; OR = 1.10, p = 0.011, respectively). We propose that the amino acid substitution affects hypothalamic-pituitary-adrenal (HPA) regulation, and hence may predispose to Bipolar Disorder. This supports the hypothesis that HPA dysregulation has a causal role in Bipolar Disorder, and is not just a consequence of the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 38, Issue 11, November 2013, Pages 2826-2829
Journal: Psychoneuroendocrinology - Volume 38, Issue 11, November 2013, Pages 2826-2829
نویسندگان
Alessandro Colasanti, David R. Owen, Detelina Grozeva, Eugenii A. Rabiner, Paul M. Matthews, Nick Craddock, Allan H. Young,