N,N′-Carbonyldiimidazole-mediated functionalization of superparamagnetic nanoparticles as vaccine carrier

▶ Magnetite (Fe3O4) nanoparticles functionalized via carbonyldiimidazole. ▶ pH affects the binding mechanism between Fe3O4 nanoparticles and ovalbumin. ▶ Improved dispersibility and low cytotoxicity after functionalization. ▶ Self-synthesized SPIONs displayed ideal characteristics as potential vaccine carrier.