Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: Influences of fatty acids

▶ The hot homogenization and ultrasonication method are feasible for preparation of enrofloxacin-loaded fatty acid SLN. ▶ The SLN have sustained release effects and can enhance the pharmacological activity of enrofloxacin. ▶ The fatty acids significantly affected the physicochemical characteristics and pharmacological activity of enrofloxacin-loaded SLN. ▶ Longer carbon chain length of fatty acid resulted in higher drug incorporation and more pronounced sustained release in vitro. ▶ The enhancement of bioavailability and systematic circulation time of the drug were significantly increased with the decrease of carbon chain length.