کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
103852 161411 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate
چکیده انگلیسی

Clobazam is a benzodiazepine with anti-anxiety and anticonvulsant properties marketed in several countries. Norclobazam, a metabolite of clobazam, has similar pharmacological activity but weaker sedative and tranquilizing effect. The two drugs were detected by GC–MS and determined by HPLC-DAD in the samples from a postmortem case. The femoral blood concentrations of clobazam and norclobazam were 0.72 and 36 μg/mL, respectively. The concentration of the active norclobazam was very high. The sum of both clobazam and norclobazam blood concentration (36.72 μg/mL) was clearly toxic, but was not necessarily fatal. Other associated drugs concentrations were within their therapeutic ranges. Interactions due to drug association were discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Legal Medicine - Volume 12, Issue 6, November 2010, Pages 300–304
نویسندگان
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