Influence of inoculum density and aeration volume on biomass and bioactive compound production in bulb-type bubble bioreactor cultures of Eleutherococcus koreanum Nakai

► In vitro conditions affect biomass and bioactive compound production in bioreactors. ► Inoculum density and aeration volume are main factors of adventitious root cultures. ► Physiological responses of roots are affected by gas components inside bioreactors. ► Optimizing culture conditions will be beneficial for the pilot-scale production. ► Eleutherococcus koreanum Nakai is an endemic medicinal plant contains useful bioactive compounds.