Inlaid Nd-substituted bismuth titanate nanoplates for protein immobilization and Nd-controlled electrochemical properties

► Layered Bi4−xNdxTi3O12 nanoplates were synthesized by sol-gel hydrothermal strategy. ► Novel biosensors were explored through employing Bi4−xNdxTi3O12 nanoplates as the supporting medium. ► The electrochemical performance of the BNTO-x-based biosensors shows regularly variable with Nd-doping content. ► Compared with other BNTO-x-based biosensors, the BNTO-0.85-based biosensor has more excellent electrochemical properties. ► The work may open up a new idea for designing third-generation electrochemical biosensors.