Evaluation of permselective membranes for optimization of intracerebral amperometric glutamate biosensors

► Several permselective membranes were studied to improve glutamate sensors in vivo performance. ► Poly(m-PD) CV shows highest performance to repel interfering compounds. ► There is no significance biofouling effect after implantation on GluOx activity. ► This sensor type has the potential to be used to monitor glutamate in brain.