Acoustic wave immunosensing of a meningococcal antigen using gold nanoparticle-enhanced mass sensitivity

► A prototype QCM-based sensor developed for detection of meningococcal antigen. ► Used a microstructured PVDF layer and Protein A layer to maximise capture of antigen by antibody. ► Conjugated gold nanoparticles to antigen to enhance the mass sensitivity of the sensor. ► Observed linear log-log calibration curve in range 312 ng/mL to 20 μg/mL of antigen.