Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo

The formation of folate targeted CD nanoparticles encapsulating RelA siRNA leads to specific folate mediated uptake in PSMA+ cells, the specific knockdown of RelA and an increase in the half-life of the siRNA188