Rational design of cancer-targeted selenium nanoparticles to antagonize multidrug resistance in cancer cells

Herein we present the rational design of a cancer-targeted selenium nanoparticles (SeNPs) drug delivery system as carrier of ruthenium polypyridyl complexes to overcome multidrug resistance and achieve enhanced theranostic effects, which allows the direct fluorescence monitoring of the selective cellular uptake and colocalization of the nanoparticles in drug resistant cancer cells.234