In vitro and in vivo anti-tumor efficacy of 10-hydroxycamptothecin polymorphic nanoparticle dispersions: shape- and polymorph-dependent cytotoxicity and delivery of 10-hydroxycamptothecin to cancer cells

10-hydroxycamptothecin polymorphic nanoparticle dispersions (HCPT-PNDs) were prepared using the supercritical anti-solvent technique coupled with high-pressure homogenization method. Polymorph-dependent tumor suppression was observed both in vitro and in vivo models. The needle-shaped HCPT-PND exhibits dramatic improvement of antitumor efficacy and non-toxic to normal tissues, which could be a potential optimized polymorphic drug in the field of nanochemotherapeutics.385