Topical application of zinc oxide nanoparticles reduces bacterial skin infection in mice and exhibits antibacterial activity by inducing oxidative stress response and cell membrane disintegration in macrophages

Graphical representation of different activities of ZnO-NPs. ZnO-NPs exhibit antibacterial, antibiofilm and intracellular killing activity, with no cytotoxicity. ZnO-NPs inhibit RBC lysis, produce ROS inside the macrophages and also reduce skin infection induced by S. aureus in mice model.110