کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10455732 921257 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: An fMRI study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: An fMRI study
چکیده انگلیسی
In the present study, we used fMRI to assess patients suffering from post-traumatic stress disorder (PTSD) or depression, and trauma-exposed controls, during an episodic memory retrieval task that included non-trauma-related emotional information. In the study phase of the task neutral pictures were presented in emotional or neutral contexts. Participants were scanned during the test phase, when they were presented with old and new neutral images in a yes/no recognition memory task. fMRI results for the contrast between old and new items revealed activation in a predominantly left-sided network of cortical regions including the left middle temporal, bilateral posterior cingulate, and left prefrontal cortices. Activity common to all three groups when correctly judging pictures encoded in emotional contexts was much more limited. Relative to the control and depressed groups the PTSD group exhibited greater sensitivity to correctly recognised stimuli in the left amygdala/ventral striatum and right occipital cortex, and more specific sensitivity to items encoded in emotional contexts in the right precuneus, left superior frontal gyrus, and bilateral insula. These results are consistent with a substantially intact neural system supporting episodic retrieval in patients suffering from PTSD. Moreover, there was little indication that PTSD is associated with a marked change in the way negatively valenced information, not of personal significance, is processed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Cognition - Volume 69, Issue 1, February 2009, Pages 98-107
نویسندگان
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