Resting-state functional connectivity in normal brain aging

► Cognitive decline occurs in neurodegenerative disorders and during normal aging. ► Resting-state fMRI is a promising neuroimaging tool to address aging and cognition. ► Brain networks are mapped by analyzing resting-state functional connectivity (RSFC). ► Aging most consistently affects the default-mode network, critical for memory. ► Aging impairs RSFC via white matter, dopaminergic and/or β-amyloid dysfunction.