Parietal cortex matters in Alzheimer's disease: An overview of structural, functional and metabolic findings

- Imaging studies in Alzheimer's disease have focussed on medial temporal lobe changes.
- Metabolic studies show the importance of the parietal lobe.
- We review evidence of involvement of the parietal lobe from various imaging studies.
- The posterior cingulate gyrus is most commonly affected in early Alzheimer's disease.
- A disease model, based on the parietal lobe, highlights the role of myelin breakdown.