Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: What have we learnt?

► GWAS and CNV studies allow better probing of the genetic makeup of major psychoses. ► Risk genes include: SZ (ZNF804A; NRGN; TCF4) and BPD (CACNA1C; PBRM1; ANK3; DGKH; NCAN). ► Genetic risk loci common to SZ and BPD include ZNF804A, CACNA1C, NRGN, PBRM1. ► Large structural deletions and duplications are more likely found in SZ than BPD. ► Integrating various platforms to unravel the genetic basis of psychoses is needed.