Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research

▶ Chemotherapy is associated with cognitive impairment in some cancer survivors. ▶ Rodent research is necessary to unravel the underlying mechanisms. ▶ This review critically evaluates current animal research addressing this question. ▶ Mechanisms include neurogenesis, white matter, inflammation, and blood flow changes. ▶ Possible intervention strategies include both drug and behavioral treatment.