Is obesity a brain disease?

- Excessive nutrition elicits early hypothalamic, hippocampal and cortical inflammation.
- Hypothalamic-inflammation disrupts energy-balance, insulin secretion and sensitivity.
- Brain insulin resistance and regional (e.g., hippocampal) atrophy evolve.
- Brain dysfunction translates into aberrant control of eating and cognitive decline.
- Brain disease is inseparable from obesity itself.