کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10461898 | 924600 | 2005 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An analysis of the genetics of alcohol intoxication in inbred mice
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کلمات کلیدی
Ataxia - آتاکسی Ethanol - اتانولLoss of righting reflex - از دست دادن رفلکس درست کردنAcute tolerance - تحمل حادBalance - تعادلRotarod - روتادورInbred mouse strains - سینه های موش درون بذرPharmacogenetics - فارماکوژنتیکactivity - فعالیتGrip strength - قدرت گرفتنIntoxication - مسمومیتCoordination - هماهنگیGenetic correlations - همبستگیهای ژنتیکیPleiotropy - پلئوتروپیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: An analysis of the genetics of alcohol intoxication in inbred mice An analysis of the genetics of alcohol intoxication in inbred mice](/preview/png/10461898.png)
چکیده انگلیسی
We compared the behaviors of eight inbred mouse strains across 18 variables, using 11 behavioral assays, and gave ethanol (EtOH) as an intoxicant. Genetic influences on behavior and sensitivity to EtOH were pronounced, but strain sensitivities were generally only modestly correlated across tasks. Certain well-correlated clusters of responses suggested that some genes affect similar neurobiological substrates. No strains of mice were generally sensitive or resistant to intoxication across tasks. Anthropomorphically appealing concepts like 'muscle strength' had little explanatory power across tasks. A battery of selected tests was proposed for future studies. Overall, the results show that each mouse behavioral assay captures only a portion of ataxia, a genetically complex behavioral domain. Conversely, multiple behavioral capacities are apparently required for performance in each specific assay. Thus, if only one or two tests are used to evaluate motor function in genetically engineered mutant mice, only a small portion of the domain will be assessed and results may be misleading. This caveat likely extends to many behavioral domains (e.g. learning and memory, anxiety).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 28, Issue 8, January 2005, Pages 785-802
Journal: Neuroscience & Biobehavioral Reviews - Volume 28, Issue 8, January 2005, Pages 785-802
نویسندگان
John C. Crabbe, Pamela Metten, Andy J. Cameron, Douglas Wahlsten,