Primary progressive dynamic aphasia and Parkinsonism: Generation, selection and sequencing deficits

MC is the first reported case of dynamic aphasia in the context of non-fluent progressive aphasia and Parkinson's disease. MC's language profile was characterised by the hallmark propositional language impairment despite well-preserved naming, reading, repetition and comprehension skills. The severity of MC's propositional language deficit was comparable to other dynamic aphasic patients. Word and sentence generation performance was severely impaired only when many competing responses were activated by a stimulus. Thus, when a dominant response was available verbal generation was satisfactory. MC also presented with a deficit in idea generation and fluent sequencing of novel thoughts as discourse generation was extremely reduced and perseverative. In addition, non-verbal generation was impaired although dissociations emerged. MC was able to generate novel designs and gestures but his performance was highly perseverative, and his motor movement selection was abnormal, resembling a non-random pattern. MC is the first dynamic aphasic case with concurrent deficits in three mechanisms thought crucial for conceptual preparation processes; namely impaired selection, impaired generation of ideas and impaired fluent sequencing of novel thoughts. The findings are discussed in relation to conceptual preparation processes and their organisation, accounts of dynamic aphasia and the roles of the left inferior frontal and basal ganglia regions in conceptual preparation processes for verbal and non-verbal generation.