Age-related changes in parahippocampal white matter integrity: A diffusion tensor imaging study

► Parahippocampal white matter volume is reduced as a consequence of normal aging. ► Age-related microstructural alterations occur in remaining parahippocampal fibers. ► Such changes may lead to partial disconnection of information flow to the hippocampus. ► Parahippocampal changes may contribute to the normal decline in memory seen in aging.