کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10465412 | 925734 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced hippocampal activity during encoding in cognitively normal adults carrying the APOE É4 allele
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
⺠Older cognitively normal APOE É4 carriers showed less activation than non-carriers in the hippocampus proper during encoding. ⺠Specifically, spatial encoding was contrasted against the dot-control task, a visually engaging non-MTL dependent control, encoding-related activation was significantly lower in carriers than non-carriers. ⺠No É4-related differences in the hippocampus were found when spatial encoding was compared with fixation. ⺠Lower activation was not global since encoding-related activation in early visual cortex (left lingual gyrus) was not different between APOE É4 carriers and non-carriers. ⺠The present study further highlights the role of low-level control tasks to tease apart the influence of genetic susceptibilities on brain activity during learning, particularly in cognitively normal middle-aged to older adults.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 49, Issue 9, July 2011, Pages 2448-2455
Journal: Neuropsychologia - Volume 49, Issue 9, July 2011, Pages 2448-2455
نویسندگان
Maheen M. Adamson, J. Benjamin Hutchinson, Amy L. Shelton, Anthony D. Wagner, Joy L. Taylor,