Chemiluminescence determination of indapamide using indapamide-imprinted polymer as recognition material

A chemiluminescence reaction between soluble Mn(IV) and indapamide was found. An indapamide MIP was synthesized and its adsorption selectivity to indapamide in aqueous solution was evaluated. Using soluble Mn(IV)-formaldehyde-indapamide chemiluminesence system as detection system and the indapamide MIP as recognition material, a selective molecule imprinting-chemiluminesence method of determination of indapamide was established. The linearly response range of this method was from 2.0 × 10−8 to 5.0 × 10−6 g/mL with a linear correlation coefficient of 0.995. The detection limit was 8 × 10−9 g/mL. The relative standard deviation for 5.0 × 10−7 g/mL of indapamide solution was 3.5% (n = 9).