کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10537045 962664 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mass spectrometry-based proteomic quest for diabetes biomarkers
ترجمه فارسی عنوان
تحقیقات پروتئومیک مبتنی بر اسپکترومتری جرم برای نشانگرهای دیابت
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia, which affects hundreds of millions of individuals worldwide. Early diagnosis and complication prevention of DM are helpful for disease treatment. However, currently available DM diagnostic markers fail to achieve the goals. Identification of new diabetic biomarkers assisted by mass spectrometry (MS)-based proteomics may offer solution for the clinical challenges. Here, we review the current status of biomarker discovery in DM, and describe the pressure cycling technology (PCT)-Sequential Window Acquisition of all Theoretical fragment-ion (SWATH) workflow for sample-processing, biomarker discovery and validation, which may accelerate the current quest for DM biomarkers. This article is part of a Special Issue entitled: Medical Proteomics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Volume 1854, Issue 6, June 2015, Pages 519-527
نویسندگان
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