Development of metal-ion containing catalysts for the decomposition of phosphorothioate esters

► Discuss categories of phosphorothioate (PPT) esters and reactions in solution. ► Mx+ catalysts promote the cleavage of PPT triesters with a bridging S in methanol. ► Discussion of the Pd(II) catalysts promoting the solvolysis of PPT pesticides. ► Quantitative measure of Pd(II) catalysis for a methanolysis of a PPT pesticide. ► Transition state bound by catalyst strong enough to convert it into intermediate.