(−)-Epigallocatechin-3-gallate stimulates both AMP-activated protein kinase and nuclear factor-kappa B signaling pathways

► EGCG stimulates AMPK- and NF-κB-signaling pathways in rat H4IIE hepatoma cells. ► EGCG acts at the transcriptional and post-transcriptional levels of the SHARP-1 gene. ► Neither EGCG nor NF-κB enhanced a 1.5-kb promoter activity of the SHARP-1 gene.