HPLC-PDA-ESI-MS/MS profiling and chemopreventive potential of Eucalyptus gomphocephala DC

► Simple, sensitive and rapid HPLC-PDA-ESI/MS/MS method was developed. ► Identification of the composition of E. gomphocephala DC. ► The antioxidant and cytotoxic activity of the different fractions were determined. ► The EtOAc fraction possessed potential antitumour-promoting properties. ► Eucalyptus gomphocephala DC. has potential chemopreventive properties.