Keywords: Cisplatin; Zileuton; 5-LOX; LTD4; LTB4;
مقالات ISI (ترجمه نشده)
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Keywords: 5-LOX; 5-lipoxygenase; AA; arachidonic acid; ANOVA; analysis of variance; AP-1; activating protein-1; CGEN; Brazilian Genetic Heritage Management Council; CIOMS; Council of International Organizations of Medical Sciences; CONCEA; National Council for the
Keywords: Donepezil-flavonoid hybrids; Neurogenesis; Neuroprotection; Sigma receptors; Human acetylcholinesterase; Human 5-lipoxygenase; Human monoamine oxidases; AChE; acetylcholinesterase; AD; Alzheimer's disease; ATCh; acetylthiocholine; BBB; blood-brain barrier
Keywords: Basophil; IgE-mediated chronic allergic inflammation; IL-4; Protease; Th2 differentiation; 5-LOX; 5-lipoxygenase; AD; atopic dermatitis; APC; antigen-presenting cell; APRIL; a proliferation-inducing ligand; BAFF; B cell-activating factor; CIU; chronic idi
Keywords: LTC4; leukotriene C4; 5-LOX; 5 lipoxygenase; NDGA; nordihydroguaiaretic acid; OA; ovalbumin; PTr; intra-tracheal pressure; SRAW; specific resistance of the airways; Nordihydroguaiaretic acid; Antigen; Airway responsiveness; Leukotrienes; Plethysmography;
Keywords: ACLY; ATP-citrate lyase; ATM; ataxia telangiectasia mutated; BCL-2; B-cell leukemia-2; Chk2; checkpoint homolog kinase 2; CiC; citrate carrier; DIC; dicarboxylate carrier; DNMT; DNA methyltransferase; FH; fumarate hydratase; H3K27; histone 3 lysine 27; HA
Keywords: Genistein; Primary muscle cells; Reactive oxygen species; 5-Lipoxygenase; Pro-oxidant; ROS; reactive oxygen species; NAC; N-acetylcysteine; 5-LOX; 5-lioxygenase; COX; cooxygenase; NOX; NADPH oxidase; GR; glutathione reductase; GCL; glutamate cysteine liga
Docosahexaenoic acid in the treatment of rheumatoid arthritis: AÂ double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil
Keywords: Rheumatoid arthritis; Docosahexaenoic acid; Docosanoids; Nutrition; Inflammation; Diseases activity; AA; arachidonic acid; ALA; α-linolenic acid; COX; cyclooxygenase; CRP; c-reactive protein; DAS28; disease activity score; DGLA; dihomo-γ-linolenic acid;
Multiple mechanisms underlying neuroprotection by secretory phospholipase A2 preconditioning in a surgically induced brain injury rat model
Keywords: SBI; surgical brain injury; PLA2; phospholipase A2; PPC; PLA2 preconditioning; 5-LOX; 5-lipoxygenase; AA; arachidonic acid; LTB4; leukotriene-B4; BWC; brain water content; WBC; white blood cells; GFAP; glial fibrillary acidic protein; MPO; myeloperoxidase
Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies
Keywords: Pyrazolone; Analgesic; Anti-inflammatory; COX-2; 5-LOX;
Synthesis, anti-inflammatory screening, molecular docking, and COX-1,2/-5-LOX inhibition profile of some novel quinoline derivatives
Keywords: Quinoline; Pyrazole; Anti-inflammatory; COX; 5-LOX; Docking;
Verification of the anti-inflammatory activity of the polyphenolic-rich fraction of Araucaria bidwillii Hook. using phytohaemagglutinin-stimulated human peripheral blood mononuclear cells and virtual screening
Keywords: Araucaria bidwillii; Anti-inflammatory; COX-II; Flavonoids; 5-LOX; Phytohaemagglutinin;
Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes
Keywords: Ligustrum vulgare; Diabetic neuropathy; Hyperalgesia; Allodynia; Oleacein; 5-LOX; 5 - lipoxygenase; ACE; angiotensin converting enzyme; CCI; chronic constriction injury; COX-2; cyclooxygenase - 2; DPN; painful diabetic neuropathy; ICAM-1; intercellular ad
Edaravone, a free radical scavenger, protects neuronal cells' mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism
Keywords: 5-LOX; 5-lipoxygenase; MCAO; middle cerebral artery occlusion; OGD; oxygen glucose deprivation; OGD-R; OGD-reperfusion; CysLTs; cysteinyl leukotrienes; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; ROS; reactive oxygen species; E
Focused library design and synthesis of 2-mercapto benzothiazole linked 1,2,4-oxadiazoles as COX-2/5-LOX inhibitors
Keywords: 1,2,4-Oxadiazole; Design; Docking; COX-2; 5-LOX; Anti-inflammatory; Anti-oxidant;
Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms
Keywords: ABC; ATP-binding cassette; ABCA1; ATP-binding membrane cassette transporter A1; ABCG1; ATP binding cassette transporter G1; ABCA7; ATP-binding cassette transporters A7; Abs; Antibodies; ACs; Apoptotic cells; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ri
Comprehensive review on flavonoids biological activities of Erythrina plant species
Keywords: 5-LOX; 5-lipoxygenase; AMPK; adenosine monophosphate-activated protein kinase; Bax; Bcl-2-associated X protein; BC; lymphoma cell line; Bcl-2; B-cell CLL/lymphoma 2; Caco2; human epithelial colorectal adenocarcinoma cells; CCRF-CEM; T lymphoblastoid cell
Role of Toll-like receptor 4/oxidant-coupled activation in regulating the biosynthesis of omega-3 polyunsaturated fatty acid derivative resolvin D1 in primary murine peritoneal macrophage
Keywords: Reactive oxygen species; Resolvin D1; Macrophages; Lipoxygenases; Toll-like receptor 4; AA; arachidonic acid; ANOVA; analysis of variance; Ï-3 DHA; omega-3 docosahexaenoic acid; ELISA; enzyme-linked immuno-sorbent assay; FBS; fetal bovine serum; iTAOC; i
In vitro and in vivo anti-inflammatory properties of imine resveratrol analogues
Keywords: 13C NMR; carbon-13 nuclear magnetic resonance; 1H NMR; proton nuclear magnetic resonance; 5-LOX; 5-lipoxygenase; AP-1; activator protein 1; AR; resveratrol analogs; BSA; Bovine serum albumin; CCL-2; C-C motif chemokine ligand 2; CD; cluster of differentia
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase
Keywords: Design; Inflammation; 5-Lipoxygenase; Pharmacophore/docking; Thiazoles; AA; Arachidonic acid; DMF; N,N-dimethylformamide; DMSO; Dimethyl sulphoxide; DPPH; 2,2 -diphenyl-1-picrylhydrazyl; EDTA; Ethylenediaminetetra acetic acid; 5-HPETE; 5(S) hydroperoxyeic
1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity
Keywords: Indole-3-glyoxamide derivatives; 1,2,3-triazoles; COX-1; COX-2; 5-LOX; Tubulin; Anti-proliferation;
Identification, signaling, and functions of LTB4 receptors
Keywords: AA; arachidonic acid; CLDN4; claudin-4; COX; cyclooxygenase; DGS3; desmoglein-3; DSS; dextran sodium sulfate; 5-LOX; 5-lipoxygenase; 5(S)-HETE; 5(S)-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5(S)-HpETE; 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic a
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX
Keywords: COX-2; 5-LOX; Pyrazole; Coumarin; Cancer;
Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action
Keywords: ALK1; activin receptor-like kinase; CDCl3; deuterated chloroform; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; DSV; discovery studio visualizer; DYRK3; dual specificity tyrosine phosphorylation-regulated kinase; CDK2; cyclin-depende
Inhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells
Keywords: 5-Lipoxygenase; Anti-angiogenic effects; Vascular endothelial growth factor signaling; CAM; chorioallantoic membrane; FBS; fetal bovine serum; HUVEC; human umbilical vein endothelial cell; VEGF; vascular endothelial cell growth factor; 5-LOX; 5-lipoxygena
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors
Keywords: 5-LOX; 5-Lipoxygenase; AA; Arachidonic acid; FLAP; 5-Lipoxygenase-activating protein; GSH; Glutathione; LT; Leukotriene; LTA4H; Leukotriene A4 hydrolase; cys-LTs; Cysteinyl leukotrienes; MAPEG; Membrane-associated protein in eicosanoid and glutathione met
Vitamin E metabolite 13â²-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice
Keywords: 13â²-COOH; 13â²-carboxychromanol; αT, γT, or δT; α, γ, or δ-tocopherol; γTE or δTE; γ, δ-tocotrienol; δT-13'-COOH or δT-13â²; 13â²-COOH derived from δT; δTE-13â²-COOH or δTE-13â²; 13â²-COOH derived from δTE; COX; cyclooxygenase; 5
2-(3â²,5â²-Dimethoxybenzylidene) cyclopentanone, a novel synthetic small-molecule compound, provides neuroprotective effects against ischemic stroke
Keywords: COX; cyclooxygenase; DMBC; 2-(3â²,5â²-Dimethoxybenzylidene) cyclopentanone; DTBHP; 3,5-di-tert-butyl-4-hydroxyphenyl; GFAP; glial fibrillary acid protein; LDH; lactate dehydrogenase; 5-LOX; 5-Lipoxygenase; MAP 2; Microtubule-associated protein 2; MCA; m
Chemical composition, biological and cytotoxic activities of Cistus salviifolius flower buds and leaves extracts
Keywords: DPPH; 1,1-diphenyl-2-picrylhydrazyl; ABTS; 2,2'-azinobis-3-ethylbenzothiazoline-6-sulphonic acid; FRAP; Ferric reducing antioxidant power; XOD; xanthine oxidase; SOD; superoxide dismutase; AChE; acetylcholinesterase; 5-LOX; 5-lipoxygenase; MeOH; methano
4-Fluoro-3â²,4â²,5â²-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model
Keywords: Invasion; Metastasis; Chalcone; QSAR; Cancer; In vivo; 5-LOX; 5-lipoxygenase; ALT; alanine transaminase; ANOVA; analysis of variance; AST; aspartate transaminase; CHI assay; chick heart invasion assay; DAPI; 4â²,6-diamidino-2-phenylindole; KDR kinase; k
Influence of vitamin C and vitamin E on redox signaling: Implications for exercise adaptations
Keywords: 5-LOX; 5-lipoxygenase; AP-1; activating protein 1; cGMP; cyclic guanosine monophosphate; ERK; extracellular signal-regulated kinase; GSH; glutathione (reduced); GSSG; glutathione (oxidized); H2O2; hydrogen peroxide; HIF-α; hypoxia inducible factor alpha;
Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors
Keywords: COX-2; COX-1; 5-LOX; Structure Based Library Design (SBLD); Virtual Combinatorial Library Design; Virtual screening; Docking study; 1,4-Dihydropyrimidine;
Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis
Keywords: Vitamin E; Lipid peroxidation; Embryogenesis; 5-LOX; 12/15-LOX; Docosahexaenoic acid; Arachidonic acid; Free radicals
Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy
Keywords: αT, βT, γT, and δT; α-, β-, γ-, and δ-tocopherol; αTE, βTE, γTE, and δTE; α-, β-, γ-, and δ-tocotrienol; AA; arachidonic acid; CEHC; carboxyethylhydroxychromans; 13â²-COOH; 13â²-carboxychromanol; 5-LOX; 5-lipoxygenase; COX-1/-2; cyclooxy
T cell regulation in microgravity - The current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilities
Keywords: 5-LOX; 5-lipoxygenase; AP-1; activator protein 1; APO; apoptosis antigen; BL; baseline; ConA; Concanavalin A; CREB; cAMP response element-binding protein; DLR; Deutsches Zentrums für Luft- und Raumfahrt, engl. German Aerospace Center; ESA; European Space
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases
Keywords: LOX; lipoxygenase; 15-LOX-2; human epithelial 15-lipoxygenase-2; 15-LOX-1; human reticulocyte 15-lipoxygenase-1; 12-LOX; human platelet 12-lipoxygenase; soybean LOX-1; soybean lipoxygenase-1; 5-LOX; human 5-lipoxygenase; COX; cyclooxygenase; AA; arachidon
Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells
Keywords: OXE-R; oxoeicosanoid receptor; OXER1; oxoeicosanoid receptor gene; AA; arachidonic acid; StAR; steroidogenic acute regulatory protein; 5-LOX; 5-lipoxygenase; 5-HETE; 5-hydroxyeicosatetraenoic acid; 5-HpETE; 5-hydroperoxyeicosatetraenoic acid; 5-oxo-ETE; 5
Potentiality and safety assessment of combination therapy with silymarin and celecoxib in osteoarthritis of rat model
Keywords: Osteoarthritis; CRP; Silymarin; 5-LOX
Photodynamic therapeutic effect of indocyanine green entrapped in polymeric nanoparticles and their anti-EGFR-conjugate in skin cancer in CD1 mice
Keywords: Photodynamic therapy; Indocyanine green; Polymeric nanoparticles; PEBBLE; Skin cancer; TNF-α; COX-2; VEGF; 5-LOX; Nitric oxide; Caspase-3; PCNA; Apoptosis
Impact of 5-lipoxygenase inhibitors on the spatiotemporal distribution of inflammatory cells and neuronal COX-2 expression following experimental traumatic brain injury in rats
Keywords: 5-LOX; 5-lipoxygenase; ANOVA; analysis of variance; BP; band pass; CA3; region 3 of the hippocampal cornu ammonis; CCI; controlled cortical impact; COX-2; isoform 2 of cyclooxygenase; CSF; cerebrospinal fluid; Cy; carbocyanine; DG; hippocampal dentate gyr
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives
Keywords: Dual inhibitors; Licofelone; COX-1/2; 5-LOX; Benzothiophene
Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro
Keywords: VLC; vacuum liquid chromatography; MA; marchantin A; SI; selectivity index; EGCG; (â)-epigallocatechin gallate; HPLC; high performance liquid chromatography; HREIMS; high resolution electron ionisation mass spectrometry; 5-LOX; 5-lipoxygenase; COX; cycl
Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators
Keywords: Cissus quadrangularis; Cycloxygenase; Inflammation; COX-1; COX-2; 5-LOX; COX-LOX inhibition; AA; Proinflammatory mediator; Nrf-2; HO-1;
HPLC-PDA-ESI-MS/MS profiling and chemopreventive potential of Eucalyptus gomphocephala DC
Keywords: Eucalyptus gomphocephala; HPLC-PDA-ESI/MS/MS; Cytotoxicity; 5-LOX; COX-2; Nitric oxide; Antioxidant;
Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors
Keywords: 4-(Benzyloxy)-1-phenylbut-2-yn-1-ol derivatives; 5-LOX; Site point connection method; In silico prediction; Carcinoma cell line; Acute lung injury
Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation
Keywords: hTERT; human telomerase reverse transcriptase catalytic subunit; hTR; human telomerase RNA component; ROS; reactive oxygen species; TNF-α; tumor necrosis factor-α; NAC; N-acetyl-L-cysteine; CHX; cycloheximide; ERK1/2; extracellular signal-regulated kina
The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology
Keywords: ABTS; 2,2â²-azino-di-[3-ethylbenzthiazoline sulphonate]; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; COX; cyclooxygenase; CNS; central nervous system; DPPH; 2,2-diphenyl-1-picrylhydrazyl; FXR; farnesoid X re
Devil's Claw-A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens
Keywords: 5-LOX; 5-lipo-oxygenase; 6â²-PCHG; 6â²-O-p-coumaroylharpagide; 8-PCHG; 8-p-coumaroylharpagide; BCL; Bicuculline; COX-2; cyclooxygenase-2; CREB; cAMP response element-binding; CYP; cytochrome P450; DAD; diode array detection; DPPH; 2, 2-diphenyl-1-picryl
Cyclooxygenases and 5-lipoxygenase in Alzheimer's disease
Keywords: AA; arachidonic acid; AD; Alzheimer's disease; CNS; central nervous system; COXs; cyclooxygenases; CysLT1; cysteinyl leukotriene 1; EP; prostaglandin E receptor; GPCRs; G protein-coupled receptors; 5-LOX; 5-lipoxygenase; LTB4; leukotriene B4; LXA4; lipoxi
CoMFA and CoMSIA studies on 5-hydroxyindole-3-carboxylate derivatives as 5-lipoxygenase inhibitors: Generation of homology model and docking studies
Keywords: 5-LOX; 3D-QSAR; CoMFA; CoMSIA; Cross validation; Homology modeling; Docking;