کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10540276 | 963403 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells
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کلمات کلیدی
SREBP-1EGFHER2PARPPiperineFASMMP-9MAPKs - MAPK هاAkt - آکتfatty acid synthase - اسید چرب سنتازApoptosis - خزان یاختهایepidermal growth factor - عامل رشد اپیدرمیMigration - مهاجرتSterol regulatory element-binding protein-1 - پروتئین 1-اتصال دهنده به سلول استرولprotein kinase B - پروتئین کیناز Bmitogen-activated protein kinases - کیناز پروتئین فعال MitogenHuman epidermal growth factor receptor 2 - گیرنده عامل فاکتور رشد اپیدرمی انسان 2
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Piperine is a bioactive component of black pepper, Piper nigrum Linn, commonly used for daily consumption and in traditional medicine. Here, the molecular mechanisms by which piperine exerts antitumor effects in HER2-overexpressing breast cancer cells was investigated. The results showed that piperine strongly inhibited proliferation and induced apoptosis through caspase-3 activation and PARP cleavage. Furthermore, piperine inhibited HER2 gene expression at the transcriptional level. Blockade of ERK1/2 signaling by piperine significantly reduced SREBP-1 and FAS expression. Piperine strongly suppressed EGF-induced MMP-9 expression through inhibition of AP-1 and NF-κB activation by interfering with ERK1/2, p38 MAPK, and Akt signaling pathways resulting in a reduction in migration. Finally, piperine pretreatment enhanced sensitization to paclitaxel killing in HER2-overexpressing breast cancer cells. Our findings suggest that piperine may be a potential agent for the prevention and treatment of human breast cancer with HER2 overexpression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 141, Issue 3, 1 December 2013, Pages 2591-2599
Journal: Food Chemistry - Volume 141, Issue 3, 1 December 2013, Pages 2591-2599
نویسندگان
Minh Truong Do, Hyung Gyun Kim, Jae Ho Choi, Tilak Khanal, Bong Hwan Park, Thu Phuong Tran, Tae Cheon Jeong, Hye Gwang Jeong,