An active peptide purified from gastrointestinal enzyme hydrolysate of Pacific cod skin gelatin attenuates angiotensin-1 converting enzyme (ACE) activity and cellular oxidative stress

► Gelatin was isolated from sea food processing by-product, Pacific cod skin. ► Extracted gelatin was hydrolysed with gastro-intestinal endo-peptidases. ► Active peptide Leu-Leu-Met-Leu-Asp-Asn-Asp-Leu-Pro-Pro was isolated. ► Peptide showed potent non-competitive ACE inhibitory activity (IC50-35.72 μM). ► Peptide protected the cellular macromolecules from oxidative damage.