Nuclear factor-kappaB as a switch in regulation of resveratrol-mediated apoptosis and erythrocytic differentiation in human leukaemia cells

► Resveratrol induced erythrocytic differentiation and apoptosis in leukaemia K562 cells. ► This was accompanied by P38 downregulation and PI3K/Akt upregulation. ► Downstream NF-κB could be a switch for the differential effects of resveratrol.