Inhibition of colon adenocarcinoma cell proliferation by flavonols is linked to a G2/M cell cycle block and reduction in cyclin D1 expression

► Red wine flavonols inhibit the proliferation of colorectal adenocarcinoma cells. ► This was mediated by their actions on the cell cycle and related signalling pathways. ► Explains the inverse correlation between colon cancer and a moderate red wine intake.