Overview on liquid chromatographic analysis of tetracycline residues in food matrices

► Antibiotic residues in food, produced from those animals, might be high due to misuse of tetracyclines (TCs). ► There is a necessity for the development of highly sensitive and selective methods for the determination of TCs in foods, because TC concentration levels are very low and food matrices are complex. ► Majority of analytical methods published in the literature for the determination of TCs in food products involve LC methods. ► During last decade LC-MS methods have been developed and implemented effectively for the determination of TCs mainly due to the known advantages of MS detection over conventional detection methods.