Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-κB activity and interleukin-1β signalling pathway

► Ginger improved TNBS-induced colitis in mice. ► Zingerone, the phenolic component of ginger, ameliorated colitis induced by TNBS. ► Ginger and zingerone significantly affected NF-κB activity and IL-1β production. ► Ginger could be used as a dietary supplement to prevent and treat patients with IBD.