An investigation into the supramolecular structure, solubility, stability and antioxidant activity of rutin/cyclodextrin inclusion complex

► We studied the structure of rutin/cyclodextrin complex using 2D ROESY 1H NMR. ► We found that the A ring of rutin inserted into the cavity of cyclodextrins. ► The complexation is an exothermic process that occurs spontaneously. ► Formation of the complex protected rutin from thermal and UV degradation. ► Formation of the complex enhanced the antioxidant activity of rutin.