Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents

► Cytokine productions of intestinal mucosal leukocytes was stimulated by P. cornucopiae extract. ► Mushroom extracts contribute to target cell adhesion in the effector immune cells. ► The promotion of cytotoxic activity by mushroom extracts is not due solely to β-glucan content.